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      <image:caption>Current Research TMTRx’s current research and development has enabled it to: ·      Demonstrated that naloxone reverses respiratory depression from morphine-derived opioids but does not appear to be effective for reversal of vocal cord closure (VCC) resulting from FFA overdose. ·      Pinpoint the potential mechanism of action(s) of FFA that leads to VCC that is not mediated by m opioid receptors (MOR) and therefore does not respond to naloxone.  ·      Identify three classes of drugs that can potentially mediate or reverse VCC.   TMTRx has: ·      Received an STTR Phase I award to test one class of drugs ·      Submitted two additional proposals to test the other two classes of drugs   TMTRx will: ·      Assess three classes of drugs in its preclinical translational model to assess the efficacy of the three classes of drugs independently and in combination with naloxone  ·      Develop formulations to treat FFA overdose ·      Address needs in medication assisted treatment ·      Develop countermeasures for weaponized FFA</image:caption>
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